Unlocking Genetic Potential: Target Flexibility and Larger Deletions With Demeetra’s Cas-CLOVER Technology
The Cas-CLOVER dimeric gene editing system has demonstrated easier screening, increased rates of knockout mutations, and versatile target design capabilities. In a collaborative webinar hosted by Demeetra and Elanco Animal Health, the parties shared data pertaining to the application of Cas-CLOVER in the development of cell lines for the bioprocessing of biological therapeutics. The discussion…
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Seedless Fruit Production With Gene Editing
Parthenocarpy, the production of seedless fruit without fertilization, occurs naturally either due to mutations or as a defense against predators. Scientists also exploit it to extend shelf life or for practical uses like large-scale sauce production and customer appeal. Seedless watermelons from grocery stores are smaller, making them easier to carry and less wasteful for…
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Taking the Potato From Genetically Engineered to Seamless Trait Development with Cas-CLOVER
In recent years, some of the biggest advances in agriculture and health have stemmed from the development of genetically engineered foods. Research teams have increased their efforts in searching for new ways of inserting exogenous genes into plant DNA for their specific traits. So far genetic engineering has shown plenty of promise and is constantly…
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RNAi Biopesticide Manufacturing In Gene Edited Heat-killed Yeast For Insect Control
According to the American Mosquito Control Association (AMCA) over 1 million people die each year from mosquito-borne diseases including Malaria, Zika, and Yellow Fever just to mention a few. In addition to its disease spreading capacity, mosquitos are a major backyard and vacation destination nuisance. New research using genome edited yeast that produce RNAi biopesticides…
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Cas-CLOVER Enables Unlimited Cell Bioprocessing Platform Improvement Opportunities
Despite the availability of established mammalian cell expression systems, the production processes for biotherapeutic proteins, antibodies, viral vectors, and vaccines remain notably laborious and financially demanding. A significant factor contributing to these high costs includes inefficiencies inherent in the platform cell lines, such as CHO (Chinese Hamster Ovary) and HEK293 (Human Embryonic Kidney 293) cells.…
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piggyBac’s Massive DNA Cargo-Carrying Capacity Simplifies And Enhances The Bioproduction Of High Value Metabolites
Using a single ~29kb vector, Demeetra’s proprietary Super piggyBac transposase stably introduced the entire 11-gene mevalonate pathway, a key metabolic component manufacturing synthetic biology (SynBio) products in s. cerevisiae. This approach can be applied to any pathway in any yeast strain without preconceived knowledge of the target site for homologous recombination. From industrial biotechnology to…
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Use Demeetra’s Toolbox For Simple Yeast Strain Development
Surgical Synthetic Biotechnology: Editing Yeast With Cas-CLOVER & piggyBac transposase Our genome editing toolbox integrates the precise cutting capability of Cas-CLOVER with the piggyBac transposase’s capacity to stably integrate large genetic cargo and facilitate seamless removal of transgenes, positioning it at the forefront of synthetic biotechnology. This document will examine the mechanisms by which these…
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