Precision gene editing for production-ready CHO cell lines.

Stable, high-performing CHO cells engineered to move biologics programs faster from sequence to clinic – powered by CleanCut CHO, Harbor-IN, and Cas-CLOVER.

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One integrated stack for stable, production-ready CHO cells

CleanCut CHO, Harbor-IN, and Cas-CLOVER work together to help biologics teams build production-ready CHO cell lines – faster, with freedom to operate.

CleanCut CHO Platform

Suspension CHO-K1 cells precisely engineered with Cas-CLOVER, optimized for high-performance bioprocessing and stable expression.

Harbor-IN

A license-free transposase designed for frictionless, high-titer commercial stable cell line development.

Cas-CLOVER

The Clean Alternative to CRISPR with IP freedom, Cas-CLOVER executes highly specific genome edits, enabling complete gene knockouts and precise site-directed knock-ins.

ADDITIONAL LICENSED TECHNOLOGY

Hyperactive Super piggyBac

A non-viral transposase system enabling high-copy gene integration for disease modeling and cell therapy research, exclusively licensed by Demeetra following its acquisition of Hera BioLabs.

  • High-copy, non-viral gene integration
  • Supports cell & reagent discovery
  • Includes transposase mRNA
  • Distinct from the core CHO/CLD platform

The Demeetra CHO Cell Line Development Advantage

How the integrated CHO/CLD platform compares to other tools.

Demeetra Platforms

Cas-CLOVER | CleanCut CHO | Harbor-IN

 Other Tools
Clear, purpose-built IP
 Encumbered or unclear IP
High precision
 Off-target effects
Discovery to production
 Limited scalability
Biopharma, CDMO, research reagents, discovery models & diagnostics
 Narrow or single-use applications
Streamlined with options
 Complex

Licensing & Purchasing Options

Demeetra offers multiple, flexible access paths aligned with how biotechnology companies build products from research through commercialization.

CHO Cell Line Development Access

CleanCut™ CHO Platform

  • Product access with a commercial pathway
  • Supports GMP and commercialization

Harbor-IN™ Transposase

  • Stable cell line development
  • No platform license required

Cas-CLOVER™

  • Targeted genome editing
  • Broad commercial rights

Super piggyBac Licensing

Super piggyBac

  • Broad commercial platform license
  • Supports cell & reagent discovery
  • Includes transposase mRNA

Why Licensing Matters

Demeetra licensing ensures clear freedom to operate and long-term support as programs move from research to commercial manufacturing.

Discovery → Development → GMP – Commercial Manufacturing

All access models are designed to support progression across the full lifecycle.

As Seen In Top Tier Publications

Our genome engineering technologies have been featured in leading publications.

Proven in Practice

Leading scientists are utilizing our platform to achieve precise and efficient results in real-world research.

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We successfully generated and confirmed gene-edited clonal cell lines within a six-week timeframe for 28 of the 30 cell lines, demonstrating the establishment of a rapid and efficient platform for gene editing in CHO cells.

McLamarrah T, Aral E, Hoffman M, et al.

Peer-reviewed study in Biotechnology Progress 2026

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Cas-CLOVER enabled >90% STAT1 knockout in HEK293 cells used for rAAV production.

Takeda Pharmaceuticals, Inc.

Andorfer et al. 2024 Biotechnol. J.

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CleanCut GS CHO pools expressing trastuzumab deliver stable, high-titer production on an accelerated timeline, lowering manufacturing costs while rapidly supplying material for development

Limia CG, Steffey V, Cheng HC, et al.

Peer-reviewed study in Biotechnology Progress 2026

Why Partner With Demeetra

We help biotech innovators accelerate discovery and scale production with technologies built for precision, efficiency, and freedom to operate

Freedom to Operate (FTO)

No entangling IP restrictions

Dual-use Technology

From research to production with the same cells & tools

Expert Support

Partnering with scientists and BD teams every step of the way

Proven Performance

Cas-CLOVER and CleanCut CHO already powering leading programs

Trusted By Leading Biotechnology Organizations

Elanco Logo
Poseida Therapeutics logo
Sanofi logo
AGC Biologics logo

Build production-ready CHO cell lines with Demeetra

Talk to our team about CHO cell line development, or explore licensing and product access – including Super piggyBac.

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