Trusted By Leading Biotechnology Companies
Cas-CLOVER, The Clean Alternative To CRISPR/Cas9
Cas-CLOVER serves as “molecular scissors” by introducing targeted double-strand breaks in genomic DNA with knockouts, knock-ins and base-pair edits.
piggyBac DNA Modification System
At elevated efficiencies, piggyBac transposase delivers any sized genetic cargo for stable and high expression. When Footprint-Free™ gene editing is required, excision-only piggyBac seamlessly removes selection markers and other genetic material
Validated In CHO Cells, Yeast and Plants
We specialize in multiple industries, allowing us to apply Cas-CLOVER and piggyBac technologies into broad real world applications.
Bioprocessing and cell line development to produce human or non-human therapeutics
Bioprocessing and strain improvement to produce therapeutics, industrial enzymes, compounds or biofuels
Enable plant modifications that may not require GMO labels and for the production of novel therapeutics
Scientists Trust Our Gene Editing Technology
“We are very happy with the efficiency of the targeted mutations we are getting with Cas-CLOVER in mammalian cells. It is impressive that although Cas-CLOVER requires dimerization it still has very high efficiency similar to CRISPR/Cas9. The one aspect of Cas-CLOVER that stood out for us was its ease of use. We have been working with CRISPR/Cas9 for many year now and Cas-CLOVER just fit in very nicely with our existing workflow for gene-editing with Cas9 or Cas9 nickase.”
Tseten Jamling, PhD.
Head of Molecular Biology
Bristol Myers Squibb
“Cas-CLOVER has several benefits to how the system works. The flexibility of the guide RNA design makes the system easy to use and gives a high specificity due to the use of two guide RNAs. It is very efficient due to the ability of the dead Cas9 to recognize the correct area of DNA, and since the Clo51 nuclease can only cut when dimerized the system has high fidelity.”
Kayla Bean, Ph.D.
Research Scientist, Discovery Research
Elanco Animal Health
Shop Cas-CLOVER Gene Editing Reagents Today
Buy Cas-CLOVER reagents for use in mammalian, plant, and yeast gene editing by visiting our easy-to-use shop page. After purchasing the vials and signing a simple royalty-free MTA form, we’ll send you our user protocols, which includes maps, sequences, instructions on design and production of the gRNAs.