Cas-CLOVER is a novel high-fidelity nuclease for safe and robust generation of TSCM-enriched allogeneic CAR-T cells
Abstract The use of T cells from healthy donors for allogeneic chimeric antigen receptor T (CAR-T) cell cancer therapy is attractive because healthy donor T cells can produce versatile off-the-shelf CAR-T treatments. To maximize safety and durability of allogeneic products, the endogenous T cell receptor and major histocompatibility complex class I molecules are often removed…
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The Ultimate Guide to Gene Editing in Wheat
The Complicated History of Wheat Wheat has had a complicated history of dispersion, adaptation, and selection since it was domesticated in the Fertile Crescent between 8,000 and 10,000 years ago. As humans migrated from the African forests into savannah regions around 6 million years ago, grass species with small, hard seeds quickly entered the human…
Read More89th American Mosquito Control Association Annual Meeting
Meet with the Demeetra team at Booth #511 to chat about the latest development strategies in mosquito control and to gain an intimate understanding of our cutting-edge larvicidal research.
Read MoreMeet Demeetra At The 5th Annual CRISPR AgBio Congress
The 5th Annual CRISPR AgBio Congress will unite research leaders, molecular biologists, regulatory experts, and product developers across the industry working to translate cutting-edge CRISPR technology into a tangible product.
Read More30th Annual Plant & Animal Genome Conference 2023
PAG30 is the premier and largest Ag genomics meeting in the world. Meet us there to learn how our gene editing tools, Cas-CLOVER nuclease and piggyBac transposase can enable research and commercial product development.
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Protein Engineered Cas-CLOVER Yields 99% Gene Editing Efficiency
At the 2022 Bioprocessing Summit, Demeetra’s Corey Brizzee presented Cas-CLOVER’s mechanism and newly engineered variants. This proven platform is enabling gene editing with extremely high efficiency and very low cell toxicity. View the presentation below. Learn more about Cas-CLOVER Read our Peer-reviewed Publications Schedule a call with us to learn more.
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Seamlessly Upgrade Your CRISPR Toolbox From Cas9 to Cas-CLOVER™
Over a decade ago, Cas9 came on the scene as the first RNA-guided nuclease, simplifying and expanding the use of gene editing. But now it’s time for an upgrade in performance and economy. Single RNA-guided Cas9 yields high off-target mutation frequencies, which often result in disruptions to product development. The small blunt-ended genomic deletions created…
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Q&A Podcast: Advanced Alternatives to CRISPR/Cas9
The field of genetic engineering is evolving much faster than most would have expected, with new techniques and discoveries announced almost weekly. Recently, Demeetra sponsored an insightful Q&A podcast with Drs. George Church and Eric Ostertag to discuss the exciting field of gene editing, and the new techniques and discoveries at Demeetra. The podcast reviews…
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