Unlocking Genetic Potential: Target Flexibility and Larger Deletions With Demeetra’s Cas-CLOVER Technology
The Cas-CLOVER dimeric gene editing system has demonstrated easier screening, increased rates of knockout mutations, and versatile target design capabilities. In a collaborative webinar hosted by Demeetra and Elanco Animal Health, the parties shared data pertaining to the application of Cas-CLOVER in the development of cell lines for the bioprocessing of biological therapeutics. The discussion…
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Seedless Fruit Production With Gene Editing
Parthenocarpy (the production of seedless fruit without prior fertilization) occurs in nature whether through a mutation that leads to negative consequences or as a benefit to shield against predators. It can also be exploited by scientists to achieve produce with longer shelf- lives or for practical purposes, such as large-scale sauce production, or more curb…
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Taking the Potato From Genetically Engineered to Seamless Trait Development with Cas-CLOVER and piggyBac Technologies
In recent years, some of the biggest advances in agriculture and health have stemmed from the development of genetically engineered foods. Research teams have increased their efforts in searching for new ways of inserting exogenous genes into plant DNA for their specific traits. So far genetic engineering has shown plenty of promise and is constantly…
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RNAi Biopesticide Manufacturing In Gene Edited Heat-killed Yeast For Insect Control
According to the American Mosquito Control Association (AMCA) over 1 million people die each year from mosquito-borne diseases including Malaria, Zika, and Yellow Fever just to mention a few. In addition to its disease spreading capacity, mosquitos are a major backyard and vacation destination nuisance. New research using genome edited yeast that produce RNAi biopesticides…
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Cas-CLOVER Enables Unlimited Cell Bioprocessing Platform Improvement Opportunities
Despite the availability of established mammalian cell expression systems, the production processes for biotherapeutic proteins, antibodies, viral vectors, and vaccines remain notably laborious and financially demanding. A significant factor contributing to these high costs includes inefficiencies inherent in the platform cell lines, such as CHO (Chinese Hamster Ovary) and HEK293 (Human Embryonic Kidney 293) cells.…
Read MoreBioProcess International 2021
BioProcess International is the largest bioprocessing event for learning how to accelerate promising biologics, cell & gene therapies toward commercial success. Join us for a presentation discussing the implementation of Cas-CLOVER for cell line development.
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piggyBac’s Massive DNA Cargo-Carrying Capacity Simplifies And Enhances The Bioproduction Of High Value Metabolites
Using a single ~29kb vector, Demeetra’s proprietary piggyBac transposase stably introduced the entire 11-gene mevalonate pathway, a key metabolic component manufacturing synthetic biology (SynBio) products in s. cerevisiae. This approach can be applied to any pathway in any yeast strain without preconceived knowledge of the target site for homologous recombination. From industrial biotechnology to agriculture…
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Use Demeetra’s Toolbox For Simple Yeast Strain Development
Surgical Synthetic Biotechnology: Editing Yeast With Cas-CLOVER & piggyBac Combining the effective targeted cutting technologies of the Cas-CLOVER platform with the large cargo loads and seamless removal capabilities of piggyBac Transposase, our proprietary genome editing toolbox is at the forefront of surgical synthetic biotechnology. First, let’s review how each of these systems work, their features…
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