Super piggyBac is a proprietary, non-viral transposase platform exclusively licensed by Demeetra following the acquisition of Hera BioLabs. Use of Super piggyBac and its derivatives, including hyperactive variants such as hyPBase, requires access to Demeetra IP.
Developed through protein engineering, Demeetra’s Super piggyBac platform is licensed for cell and gene therapy research and development, as well as for commercial use in research reagents, model development, and diagnostic applications.
Synergistic Hyperactive Mutations Drive Super piggyBac Efficiency
Super piggyBac was created through the systematic combination of multiple hyperactive mutations, resulting in a next-generation transposase engineered to deliver both high integration efficiency and elevated transgene copy number in cell types critical for cell and gene therapy research and development, while preserving piggyBac’s large cargo capacity and favorable open-chromatin integration profile.
Super piggyBac achieves several-fold higher CAR-T and GFP integration in primary cells, producing stronger, more uniform engineered populations for cell therapy research and development.
Super piggyBac® demonstrates markedly superior performance compared to wild-type piggyBac and competitor transposases, delivering both higher integration efficiency and substantially increased transgene copy number in relevant cell systems. Super piggyBac performs comparably to hyPBase, a hyperactive derivative that itself requires access to Demeetra IP, reinforcing Super piggyBac as a best-in-class, IP-controlled platform for high-performance gene integration.
Validated for Commercial Research
Super piggyBac is proven across diverse applications in drug discovery, diagnostics, and product development
Ready to Advance Your Programs?
Super piggyBac® delivers high-efficiency, non-viral gene integration with elevated copy number across primary cells and mammalian systems, supporting advanced cell and gene therapy research, commercial research tools, and model development. Backed by exclusive Demeetra IP and validated performance, Super piggyBac provides a confident foundation for high-impact cell engineering programs.