CLOVER Gene Editing Technology Licensed to Hudson River Biotechnology
CLOVER Gene Editing Technology Licensed to Hudson River Biotechnology LEXINGTON, KY – Demeetra AgBio, a pioneer in precision gene editing technologies for commercially applicable systems, is proud to announce that Hudson River Biotechnology has officially in-licensed our cutting-edge CLOVER genome editing tool. This strategic partnership marks a significant milestone in advancing agricultural biotechnology and sustainable crop production. The…
Read MoreDemeetra to Present Preclinical Data on Investigational Cannabinoid Derivatives at the 2025 Crohn’s and Colitis Congress
Demeetra to Present Preclinical Data on Investigational Cannabinoid Derivatives at the 2025 Crohn’s and Colitis Congress Novel non-natural small molecules DM350-P and DM300 outperform natural cannabinoids, steroid and immune suppressant positive controls in a mouse Colitis and rat Crohn’s model. The data presented will highlight the significant impact of medicinal chemistry on cannabinoid pharmacology, demonstrating…
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Bioprocess International 2024 Poster Presentation: Cas-CLOVER-mediated knockout of STAT1: A novel approach to engineer packaging HEK293 cell lines used for rAAV production
Bioprocessing International 2024 Poster: Cas-CLOVER-mediated knockout of STAT1: A novel approach to engineer packaging HEK293 cell lines used for rAAV production To address the limitations of CRISPR-Cas9, including off-target effects and high licensing costs for commercial use, the Cas-CLOVER system, a dimeric gene-editing tool activated by two guide RNAs, was recently developed. Here we evaluated…
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BPI West 2024 Poster Presentation: piggyBac Transposase and Cas-CLOVER Targeted Nuclease Enable Rapid Discovery of Novel Hot Spots in HEK293 Suspension Cells
BPI West 2024 Poster Presentation: piggyBac Transposase and Cas-CLOVER: CRISPR-based Innovations Enable Rapid Discovery of Novel Hot Spots in HEK293 Suspension Cell Line Development Cell factory platforms are used in commercial bioproduction to express therapeutic molecules such as antibodies, vaccines, and biosimilars. Through innovative gene editing tools, cell lines can be tailor-made to stably express…
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Demeetra Cas-CLOVER Research Selected as a MDPI Journal Editor’s Choice Article
Demeetra Cas-CLOVER Research Selected as a MDPI Journal Editor’s Choice Article Lexington, KY and Bloomington, IN: A pioneering study, authored by scientists from Demeetra and Indiana University, has been selected for the MDPI Journals Editor’s Choice Articles, highlighting the impact of advanced gene editing in synthetic biology to produce biopesticides. Published in Fermentation in 2023, Generation…
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GEN Webinar: Cas-CLOVER: The Clean Alternative to CRISPR-Cas9
In this 2020 introductory webinar “Cas-CLOVER: A Clean Alternative to CRISPR,” two experts present data on Cas-CLOVER fundamentals such as architecture, design and implementation in cells, yeast, plants as well as advanced gene editing in human T-cells for allogeneic CAR-T therapies. Thanks to GEN: Genetic Engineering and Biotechnology News for hosting.
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Demeetra’s Guide to CRISPR Gene Editing Licensing
Demeetra’s Guide to CRISPR and Gene Editing Licensing Figure 1: A general schematic of CRISPR’s simple single gRNA mechanism and function. Includes two outcomes: error-prone repair, which generally results in a LOF mutation, and template-based repair where genetic functionality is altered and genome is changed. While today many scientific articles present a simple process of…
Read MoreERS Genomics & Demeetra Enter Into CRISPR/Cas9 Licensing Agreement
Dublin, Ireland and Kentucky, USA, September 12: ERS Genomics Limited (‘ERS’) is pleased to announce a new license agreement with Demeetra AgBio (‘Demeetra’). This is a non-exclusive licensing agreement granting Demeetra access to the ERS CRISPR/Cas9 patent portfolio which is sublicensable when combined with Cas-CLOVER.
Read MoreGuide RNA Design For Cas-CLOVER
Dimerization of our Cas-CLOVER gene editing technology requires the design of two guide RNAs (gRNAs) to the gene of interest.
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A piggyBac-mediated transgenesis system for the temporary expression of CRISPR/Cas9 in rice
Targeted mutagenesis via CRISPR/Cas9 is now widely used, not only in model plants but also in agriculturally important crops. However, in vegetative crop propagation, CRISPR/Cas9 expression cassettes cannot be segregated out in the resulting progenies, but must nevertheless be eliminated without leaving unnecessary sequences in the genome. To this end, we designed a piggyBac-mediated transgenesis…
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