Special Offer For Non-Profit Researchers For Cas-CLOVER Gene Editing Technology

Shop Cas-CLOVER reagents for research or commercial applications and without license fees.

a21104a5-demeetra-cas-clover_10hi07v0h307v007000028

Are you conducting gene editing in cells, animals, plant or yeast for a non-profit organization? Would you like the opportunity to commercialize the gene edited products, or traits? If so, we have a special offer for you.

Our Cas-CLOVER gene editing system “the clean alternative to CRISPR-Cas9” is now available without license fee only for not-for-profit researchers. In order to remove restrictions typical of other gene editing technologies, our MTA includes a path to commercialization of materials produced by your lab (in our joint fields of use including: research, drug discovery, bioprocessing, agriculture & industrial biotechnology).

In order to take advantage of this offer, simply complete your purchase of Cas-CLOVER reagents below with the option for us to design your guides. We will provide our standard use protocol, which includes maps, sequences, instructions on design and production of the gRNAs.

All reagent prices include shipping & handling. The mammalian mRNA product requires shipping on dry ice and costs more to ship.

Shop Cas-CLOVER Reagents

Mammalian gene editing

2e2a2f95-icon4_104q04q000000000000000
Mammalian Codon Optimized Cas-CLOVER mRNA
SKU: D001

Improved mRNA stability and protein expression in mammalian systems. Order custom designed and produced gRNAs from us (see options below) or your favorite provider and transform with the mRNA for clean editing.

25µg vial

$800

Plant gene editing

4bd0da13-icon2
Plant Cas-CLOVER Gene Editing Plasmid Vector Suite

T-DNA based plant transformation vectors for gene knockout in plants using the Cas-CLOVER system. The system is codon optimized for plant expression. Expression promoters for Cas-CLOVER, gRNA’s, selection markers and other details are listed below along with links to the maps.

All vectors are 5µg vial

$99
Plasmid Sku#Codon OptimizationCas-CLOVER PromotergRNA PromoterHost SelectionBacterial SelectionPlasmid NotesMap linkAdd to cart
pDMT1-1A. thalianaCaMV35SOsU3HygromycinKanamycinSequential cloning of gRNAsMap$99
pDMT3-4A. thalianaCaMV35SAtU6-26HygromycinKanamycinSequential cloning of gRNAsMap$99
pDMT1-123A. thalianaCaMV35SOsU6HygromycinKanamycinSequential cloning of gRNAsMap$99
pDMT1-112A. thalianaCaMV35SOsU3KanamycinKanamycinSequential cloning of gRNAsMap$99
pDMT1-114A. thalianaCaMV35SAtU6-26KanamycinKanamycinSequential cloning of gRNAsMap$99
pDMT1-116A. thalianaCaMV35SOsU3GlufosinateKanamycinSequential cloning of gRNAsMap$99
pDMT1-118A. thalianaCaMV35SAtU6-26GlufosinateKanamycinSequential cloning of gRNAsMap$99
pDMT1-136A. thalianaCaMV35SAtU6-26-Two guide systemHygromycinKanamycinTwo guides cloned via GGAMap$99
pDMT1-137A. thalianaCaMV35SOsU3-Two guide systemHygromycinKanamycinTwo guides cloned via GGAMap$99
pDMT1-138A. thalianaCaMV35SOsU6-Two guide systemHygromycinKanamycinTwo guides cloned via GGAMap$99
pDMT1-142A. thalianaCaMV35SAtU6-26-Two guide systemKanamycinKanamycinTwo guides cloned via GGAMap$99
pDMT1-143A. thalianaCaMV35SOsU3-Two guide systemKanamycinKanamycinTwo guides cloned via GGAMap$99
pDMT1-144A. thalianaCaMV35SOsU6-Two guide systemKanamycinKanamycinTwo guides cloned via GGAMap$99
pDMT1-145A. thalianaCaMV35SAtU6-26-Two guide systemGlufosinateKanamycinTwo guides cloned via GGAMap$99
pDMT1-146A. thalianaCaMV35SOsU3-Two guide systemGlufosinateKanamycinTwo guides cloned via GGAMap$99
pDMT1-147A. thalianaCaMV35SOsU6-Two guide systemGlufosinateKanamycinTwo guides cloned via GGAMap$99

GGA=Golden Gate Assembly

Yeast Gene Editing

c3d9a499-icon3
Yeast Cas-CLOVER Gene Editing Vector Suite

We offer a series of yeast-based shuttle vectors for the expression of a Saccharomyces cerevisiae codon optimized version of Cas-CLOVER. In this platform we have designed the plasmids such that gRNA expression is polyscistronic. Expression is driven by ScDMPR1, a proprietary promoter (information will be provided following your purchase), and individual guides are liberated via an intervening tRNA. Plasmids are offered on low copy CEN/ARS origin of replication.

Plasmid Sku#Codon OptimizationCas-CLOVER PromotergRNA PromoterHost SelectionHost ReplicationBacterial SelectionNotes About PlasmidMap linkAdd to cart
pDMT1-124S. cerevisiaeScDMPR1No Guide Expression CassetteLEU2CEN/ARSAmpicillinBsaI sites have been mutated.Map$99
pDMT1-125S. cerevisiaeScDMPR1ScSNR52LEU2CEN/ARSAmpicillinTwo guides can be cloned via GGAMap$99
pDMT1-126S. cerevisiaeScDMPR1ScSNR52URA3CEN/ARSAmpicillinTwo guides can be cloned via GGAMap$99
pDMT1-127S. cerevisiaeScDMPR1ScSNR52KanRCEN/ARSAmpicillinTwo guides can be cloned via GGAMap$99
pDMT1-128S. cerevisiaeScDMPR1ScSNR52HygRCEN/ARSAmpicillinTwo guides can be cloned via GGAMap$99

GGA=Golden Gate Assembly

Cas-CLOVER gRNA Design & Production Services

1w7u1xu-icon_105705c057058000002000
Cas-CLOVER gRNA Design Services
SKU: D004-1

Synthesis of 1 gRNA using state-of-the-art methods to be used for gene editing with Cas-CLOVER

1 gRNA

$99
1w7u1xu-icon_105705c057058000002000
Custom gRNA Production Services
SKU: D005

Synthesis of 1 pair (two gRNAs) using state-of-the-art methods to be used for gene editing with Cas-CLOVER

1 pair gRNA

$299

Validated in CHO Cells, Yeast, Plants & Human T-Cells

Cas-CLOVER has been validated in CHO cell lines and yeast for bioprocessing, plants for crop trait engineering and human T-cells for immunotherapy research..

To learn more about the area you are interested in, download the relevant industry datasheet.

drug

Drug Discovery & Development

Advancing cell-line engineering for pharmaceutical research

e1989d92-hera-logo
bioprocessing

Therapeutic Bioprocessing

Clean & clear CHO cell editing and GS CHO knockouts for bioprocessing

y99zlk-logo_103v01j03t01j000000000
agriculture

Agriculture

Advanced crop trait engineering, the non-GMO way

y99zlk-logo_103v01j03t01j000000000
c3d9a499-icon3

Industrial Biotechnology

Harnessing the power of targeted yeast editing

y99zlk-logo_103v01j03t01j000000000

Watch Our Videos

Enhance your gene editing research interests with Cas-CLOVER. The recorded webinars hosted by Genetic Engineering & Biotechnology News are available below so that you can watch the areas that apply to your research.

You can also watch our video on how Cas-CLOVER is a more efficient gene editing tool than CRISPR.

9072c50e-5d2139f5-5b7c-46f3-a5bb-2e40eaa4e75f

Tseten Jamling, PhD.

Vice President,
R&D and Gene Editing
Hera BioLabs

Cas-CLOVER fundamentals, immunotherapy model creation, CHO cell editing, yeast, & plant trait development.

16b6ebb1-cb0e1511-c15a-4279-94ab-4d9efb8b4262

Maximilian Richter, PhD.

Senior Scientist,
Immuno-Oncology
Poseida Therapeutics

Advanced T-cell engineering to overcome known challenges with autologous CAR-T.

Get A Jump Start On Your Research

Procure Cas-CLOVER reagents by our easy-to-use shop page by simply purchasing the vials and signing a simple royalty-free MTA form.

Shortly after your purchase, you’ll get our basic use protocol, which includes maps, sequences, instructions on design and production of the gRNAs.

Get started on your academic research today.

We Enable Scientists To Obtain More With Less Inconvenience

Contact us to learn more about our gene editing technology.

DEMEETRA AGBIO, INC.

2277 THUNDERSTICK DR. #500 LEXINGTON, KY 40505 US

COPYRIGHT © 2020 DEMEETRA AGBIO, INC. - ALL RIGHTS RESERVED.