Unlock the Full Potential of Biologics Manufacturing
Harbor-IN is uniquely suited for bioproduction, streamlining cell line development and enabling high-titer protein expression without the need for labor-intensive process intensification strategies.
✔ Achieve Titers >8 g/L – Demonstrated in CHO cells expressing monoclonal antibodies under GS selection.
✔ Non-Viral, Stable Integration – Avoids the risks associated with viral vectors, ensuring regulatory compliance and genomic integrity.
✔ Flexible Cargo Capacity – Efficiently integrates large genetic payloads (>200 kb).
License-Free Commercial Use: Freedom to Operate
Unlike many transposases that require time consuming and expensive licensing agreements, Harbor-IN is available for unrestricted commercial use. With the purchase of Harbor-IN, companies gain full access to a powerful transposase system for applications in cell line development, bioprocessing—without any additional fees.
How It Works
Harbor-IN integrates genetic material into safe genomic sites, favoring highly transcribed, open chromatin regions for maximal and stable gene expression.
Harbor-IN Starter Kit: Fast-Track Your Development
The Harbor-IN Starter Kit includes:
- Optimized mRNA Transposase (25 µg) for efficient genomic integration
- Four Pre-Validated Transposon Plasmids for streamlined selection and expression
- Transposon plasmids possess multiple cloning sites (MCS) for efficient cloning
Combine Harbor-IN with our Biologics Expression Platforms
Whether you're developing monoclonal antibodies or other recombinant proteins, Harbor-IN provides a scalable, efficient, and cost-effective solution for stable gene integration—without licensing barriers.
Harbor-IN is fully compatible with Demeetra’s CleanCut GS CHO cell platform, enabling high-efficiency, stable gene integration for biologics production. This combined system has demonstrated industry-leading cell-specific productivity, optimizing recombinant protein expression. Further platform enhancements can be achieved through Cas-CLOVER targeted nuclease technology, facilitating precise knock-ins at high-expression genomic loci to further enhance productivity and downstream processes.
