Demeetra AgBio
Demeetra AgBio
Demeetra AgBio

BioProcess International 2021

  • September 20-23, 2021
  • Boston Convention and Exhibition Center
Demeetra AgBio

Join Us in Person or Online at BioProcess International 2021

Be sure to visit us at BPI 2021 at booth 554 inside the Boston Convention and Exhibition Center in Boston, MA from September 20th - 23rd. You can also access all recorded presentations online and attend the live, virtual event from September 28th - 30th.

Attend the Cas-CLOVER Presentation by Sanofi

We’re excited to announce that Sanofi, a leading global biopharmaceutical company focused on human health, will present the implementation of Cas-CLOVER for cell line development at BioProcess International.

Demeetra AgBio

In her presentation, “High-throughput gene editing of CHO-K1 cells using Cas-CLOVER,” Tiffany McLamarrah, a Scientist in Cell Line Development at Sanofi, will present her work in editing 30 individual CHO cell lines with Cas-CLOVER in just a few months.

Tiffany works on enhancing biologic protein production platforms specializing in enhancing the CHO host cell lines through genetic engineering and phenotypic screens.

A Cleaner, More Efficient Alternative to CRISPR-Cas9

Cas-CLOVER is a hybrid gene editing system using a nuclease-inactivated Cas9 protein fused to a Clo51 endonuclease.​ This technology helps eliminate off-target mutations and is available through simple single licenses with distinct issued IP.

Demeetra AgBio

Achieve Optimized Precision with Cas-CLOVER

As opposed to the use of a single guide RNA (gRNA) like in CRISPR, the Cas-CLOVER system utilizes two gRNAs in addition to the Clo51 nuclease activity that requires dimerization of subunits associated with each guide RNA. This allows for more stringent DNA cleavage.

Demeetra AgBio
Demeetra AgBio

Exclusive Patents Allow for Freedom to Operate

Current gene editing tools, particularly CRISPR, are held back by confusing intellectual property restrictions. This lack of commercial freedom to operate has limited CRISPR’s applications.

Cas-CLOVER, exclusively licensed and sublicensed by Demeetra AgBio, is covered under a set of patents separate from other technologies and therefore, easy to license.

More About BPI 2021

BioProcess International is the largest bioprocessing event for learning how to accelerate promising biologics, cell & gene therapies toward commercial success.

Participants are able to access novel science, technologies and contacts to improve efficiencies across the entire spectrum of biopharmaceutical development and production.

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