Bioprocessing Summit 2025
Multiplexing with Accuracy: Building Better CHO Platforms with Cas-CLOVER
Speaker: Corey Brizzee, Director, Gene Editing, Demeetra
Abstract
Cas-CLOVER’s dimeric nuclease enables precise GS knockouts (Chr1 & Chr5), creating the CleanCut™ GS CHO platform. Derivative lines reduce HCP expression by disrupting 6–7 alleles in one transfection. This highlights Cas-CLOVER’s efficiency, scalability, and precision in engineering complex traits for next-gen biologics manufacturing.